Ayurveda and Cancer

Over 5000 years ago, Ayurveda emerged as a comprehensive integrative therapeutic method. The term "Ayurveda" refers to the science of life, with "Ayus" standing for life and "Veda" for knowledge. The three principal ancient writings are the Ashtanga Hridaya, a more condensed and lyrical synopsis of the first two texts, the Sushruta Samhitas, which deal with surgery and medicinal concepts, and the Charaka Samhita, which is the primary work containing fundamental principles of Ayurveda and internal medicine. Thousands of herbal formulas for various health ailments as well as detailed descriptions of over 400 herbs and daily and seasonal routines are included in these incredibly detailed texts, along with advice on healthy diets. Ayurveda provides a comprehensive, individualized approach to treatment that takes into account a person's body type, digestive system, immunity, and mental well-being. 

The present allopathic understanding of physiology is strikingly congruent with the notions of physiology found in the old Ayurvedic writings. The texts offer insights into pathology and normal physiology, as well as distinctive viewpoints on the early phases of disease that might be applied to early detection tactics. They offer comparatively low-tech, straightforward instructions for preserving and reestablishing the ecological balance of our bodies and relationships with the physical, social, and environmental worlds.

In the quest to advance our understanding and treatment of cancer, integrating insights from diverse medical systems can provide valuable perspectives and novel approaches. Ayurveda, a traditional Indian system of medicine with a rich history spanning over 5,000 years, offers a unique lens through which we can examine the complexities of cancer biology, treatment, and supportive care. By exploring the principles and practices of Ayurveda, we may uncover new avenues for research and innovation in modern oncology. This article delves into the potential applications of Ayurvedic knowledge in the context of contemporary cancer care, highlighting how this ancient wisdom can complement and enhance our current understanding of this complex disease. Through examining the Ayurvedic perspectives on cancer development, treatment, side effect management, and supportive care, we aim to foster a dialogue between traditional and modern medicine, ultimately paving the way for a more integrative and patient-centered approach to cancer care in the 21st century.

Executive Summary

  • Ayurveda's History: Originating over 5,000 years ago, Ayurveda is grounded in ancient Hindu philosophical traditions. Its core principles revolve around the balance of five elements (Pancha Mahabhoota), three primary humors (Tridoshas), seven tissues (Dhatus), and waste products (Malas).

  • Ayurvedic Understanding of Cancer: Ayurveda views cancer as a result of imbalances in Doshas and Dhatus, influenced by factors like genetics, immunity, diet, and environment. This aligns with modern understandings of cancer's complexity.

  • Ayurvedic Cancer Classification: Cancers are classified based on involved Doshas (Vataja, Pittaja, Kaphaja, Tridoshaja) and tissues (Medaja, Mamsaja, Raktarbuda).

  • Ayurvedic Treatment Approaches: Rasayana therapy, a core Ayurvedic practice, focuses on rejuvenation and homeostasis through herbs, formulations, diet, and lifestyle modifications. Specific herbs like allspice, basil, cinnamon, cumin, garlic, and ginger are discussed for their potential anticancer properties.

  • Diet and Nutrition: Ayurveda emphasizes a balanced diet (Ahara) based on individual constitution (Prakriti). Sattvic foods are recommended, while Rajasic and Tamasic foods are to be moderated or avoided.

  • Lifestyle Modifications: Stress management through mind-body practices like meditation and yoga is highlighted. Sleep hygiene is also discussed, considering its potential impact on cancer risk.

  • Detoxification and Cleansing: Panchakarma therapy, a detoxification process, aims to eliminate toxins and restore balance. It involves three stages: Purvakarma (preparation), Pradhanakarma (cleansing), and Pashchat karma (post-detoxification).

Ayurveda and Cancer: An Interview With Dr. Gaurav Desai on the Use of Ayurveda in Cancer Care and Treatment | May 2024

The History of Ayurveda

Ayurveda has been practiced since the second century BC. The ancient Hindu philosophical traditions Vaisheshika and Nyaya, known for their reasoning, established the groundwork for Ayurveda. It was founded during the same time as the schools of Nyaya and Vaisheshika developed, and it is also connected to the manifestation framework, also referred to as Samkhya.

Inferences and perceptions on a patient's pathological condition should be collected for therapy purposes, according to the Vaisheshika School's teachings. On the other hand, the Nyaya school spread its beliefs based on the idea that before beginning treatment, one should have a thorough understanding of the patient's condition as well as the state of the disease. The Vaisheshika school divides an object's qualities into six categories: substance, particularity, activity, generality, inherence, and quality. These categories are known in Sanskrit as Dravya, Vishesha, Karma, Samanya, Samavaya, and Guna, respectively. Subsequently, the Vaisheshika and Nyaya schools collaborated to establish the Nyāya–Vaiśeṣika school. Later on, the nyāya–vaiūeṣika school promoted Ayurveda and elevated the status of traditional knowledge.

The knowledge of traditional remedies was transmitted from the sages to their followers and then to the general public through a variety of written and oral traditions. The "Shlokas," or poetry, contained information on the medicinal qualities of the herbs. The Yajur, Rig, Sam, and Atharva Vedas are four highly regarded collections of knowledge that are considered to be the foundation of the Hindu medical system. Of the four Vedas, the Rig Veda is the most well-known and contains descriptions of 1028 Shlokas and 67 plants. 293 and 81 helpful medicinal plants, respectively, are described in the Atharva and Yajur Vedas. These Vedas provide the foundation for Ayurvedic knowledge and practice. 

The texts included in the Rig Veda and Atharva Veda are credited to "Atreya," who is said to have learned these teachings from Lord Indra, who in turn learned them from Lord Brahma. Agnivesha assembled the Vedic wisdom, which Charaka and a few other academics edited to create what is now known as the "Charaka Samhita." The entirety of Ayurvedic medicine is covered in the Charaka Samhita, and the science of surgery is covered in the Sushruta Samhita, and so on Traditional medicine practitioners still employ both of these fabled compilations. Numerous translations and languages, including Tibetan, Greek, Chinese, Arabic, and Persian, are accessible for these ancient texts.

Ayurvedic Understanding of Cancer

Fundamental principles of Ayurveda

According to Ayurveda, the five elements of Vayu (air), Jala (water), Aakash (space or ether), Prithvi (earth), and Teja (fire) make up the entire universe. It is thought that these five components (Pancha Mahabhoota) combine to generate the three primary humors of the human body. The term "Tridoshas" refers to the three humors, Vata, Pitta, and Kapha, which together govern the fundamental physiological processes of the body and each of the three primary doshas has five sub-doshas. According to Ayurveda, there are seven different types of tissues in the human body: Rasa (tissue fluids), Meda (fat and connective tissue), Rakta (blood), Asthi (bones), Majja (marrow), Mamsa (muscle), and Shukra (semen). There are also three types of waste products called Malas, which include Purisha (feces), Mutra (urine), and Sweda (sweat). 

Vata dosha is enhanced by dryness and is responsible for cellular transport, electrolyte balance, and waste product removal. Pitta dosha controls thirst and hunger, as well as body temperature and optic nerve function. The body's temperature increases worsen Pitta. Sweet and fatty foods raise the Kapha dosha, which lubricates the joints to allow for optimal function. It is thought that Vata controls the body's catabolism, Pitta controls metabolism, and Kapha controls anabolism. The three doshas should be in balance, together with other elements, for optimal health. A condition of illness or disease results from any imbalance among the three.

Ayurvedic principles state that sickness cannot be called on its own because each person's ailment, clinical presentation, and required treatment are unique. Thus, Tridoshas provides the cornerstone for the Ayurvedic explanation of etiology. Every single cell in the human body contains Agni or Pitta, which is in charge of metabolism and digestion. The inverse relationship between agni and the corresponding tissue dictates that a lowered state of dhatwagni (the role of agni in metabolism) in arbuda (tumor) will lead to excessive tissue growth.

In addition to the Doshas and Dhatus, the Tri Malas and Trayo Dosa Agni are significant components of Ayurvedic theory. The three categories of waste products known as "tri malas" are produced by the body as a result of its metabolic and digestive processes. They are made up of the Sveda (sweat), Purisa (feces), and Mutra (urine). According to Ayurveda, if the equilibrium between the Tridosha is upset, the body's waste products are not properly expelled, which can result in more issues like constipation, diarrhea, asthma, rheumatoid arthritis, and other issues. UTIs, cystitis, and stomach discomfort can result from the body's failure to eliminate Mutra Mala or urine. Skin rashes and imbalanced fluids can result from the Sveda Mala if it is not eliminated from the body.

What is Prakriti?

In Ayurveda, the term "Prakriti" refers to an individual's innate makeup or state of being, which is established by the vata, pitta, and kapha doshas' equilibrium. These doshas are unique to each individual and have an impact on their mental, emotional, and physical traits. Understanding which of these doshas predominates in your body is necessary to determine your Prakriti. Here's how to figure out what your Prakriti is:

  • Self-Assessment Questionnaire:
    To ascertain your predominant dosha or Prakriti, there are a plethora of self-assessment questionnaires available online or in Ayurvedic publications. These surveys usually inquire about your interests and inclinations in addition to a variety of your mental, emotional, and physical traits.

  • Speaking with an Ayurvedic Practitioner:
    It's best to speak with an Ayurvedic practitioner if you're unclear about your Prakriti or would need a more precise evaluation. A variety of techniques, such as pulse diagnosis, observation, and in-depth questioning regarding your habits, lifestyle, and medical history, can be used to assess your Prakriti.

  • Examining Your Mental and Physical Features:
    Consider your mental and physical characteristics. Vata types are typically medium-built and have dry skin, Pitta types are medium-built and have warm bodies, and Kapha types are typically sturdy and have oily skin. Examine your mental and emotional inclinations as well. For example, Vata types tend to be creative but also anxious, Pitta types are ambitious but also prone to wrath, and Kapha types are peaceful but also prone to laziness.

  • Reactions to Food, Climate, and Environment:
    Pay attention to how your body and mind respond to various foods, surroundings, and climates. Vata types can have irregular digestion and be more susceptible to cold, dry conditions. While Kapha types may be more susceptible to damp, chilly weather and heavy, oily foods, Pitta types may be more sensitive to heat and spicy foods.

  • Consider Your Preferences and Natural Habits:
    Consider your innate traits, tastes, and routines. While Pitta types are driven, structured, and competitive, Vata types are typically imaginative, impulsive, and flexible, while Kapha types are nurturing, steady, and routine-focused.

Ayurvedic perspective on cancer development 

According to the classic scriptures of Ayurveda, malignancies are classified as either non-inflammatory or inflammatory swellings named Granthi (a mild neoplasm) or Arbuda (a significant neoplasm). The meaning of these names has changed over time; "Arbuda" is now translated as a benign cystic node, nodule, swelling, or glandular enlargement, and "Granthi" as a spherical, big, muscular, immovable, or swelling "tumor."

Theories of early disease detection, etiology, and pathogenesis—known as "Samprapti," or disease progression—are woven throughout Ayurvedic scriptures. "Shat Kriya Kala" refers to the six stages of pathogenesis. This is a gradual process that can take years to complete. It involves the buildup of Ama and inflammation in the tissues, as well as the escalation of doshas that have been weakened by an improper diet or other contributing causes.

Cancer is not viewed by Ayurveda as a separate illness or group of illnesses. Rather, according to Ayurveda, all illnesses come from severe, systemic imbalances and problems with the three Doshas. As previously stated, aberrant Doshas and weaker Dhatus interact to cause some diseases, such as cancer. For instance, there is a common link between cancer and diabetes due to the vitiation of Kapha Dosha; however, the organs (Dhatus) that are impacted are different. Therefore, although excess and poorly created Meda (adipose tissue) interacting with vitiated Kapha Dosha might cause diabetes, inadequate Shukra Dhatu (tissue regeneration and cell division) interacting with vitiated Vata Dosha and Kapha Dosha could lead to cancer. Because each person has a unique pattern of pathogen exposure and dynamic changes in Dhatus functioning, the severity of sickness and clinical manifestation of cancer are thought to vary.

Cancer was formerly believed to be caused by a series of genetic processes that controlled cell division and proliferation. The phenotype of a cancer patient is now known to be strongly impacted by anomalies involving immunological function, food, environmental variables, and epigenetic control. Ayurveda also views nutrition and surroundings as key modulators of Agni and immunity, which can raise the risk of cancer. The idea of "shared pathology" between metabolic syndrome and cancer bears some resemblance to the Ayurvedic theory that weak tissues (Dhatus) and vitiated Doshas combine to cause systemic dysfunctions that can materialize as organ malignancies. Because inflammation and dyslipidemia have an "indirect" role in the development of cancer, several anti-inflammatory and antidiabetic medications are effective against cancer. Because treatments seek to eradicate vitiated Doshas, revitalize bodily processes, and boost immunity, Ayurveda also employs "indirect" methods to treat cancer (Rasayanaprayoga).

Ayurvedic classification of cancers

Classification according to doshas involved:

According to Ayurveda, malignancies are categorized according to which doshas predominate in the body. Every kind of cancer, called "Arbuda" in Ayurveda, has unique characteristics and accompanying symptoms. Gaining an understanding of these divisions can help identify suitable treatment approaches and offer insightful information about the nature of the illness.

  • Vataja Arbuda is mostly affected by the Vata dosha, which stands for the components of air and ether. The characteristics of this kind of cancer are fast development, erratic boundaries, and a propensity for rapid dissemination. Symptoms of Vataja Arbuda include heightened sensitivity to touch, restlessness, dryness in the affected area, and unexplained weight loss.

  • Pittaja Arbuda, which stands for the elements of fire and water, is connected to the Pitta dosha. This kind of cancer has a propensity to bleed and shows symptoms of heat, redness, and inflammation. Pittaja Arbuda patients may be afflicted with fever, burning in the affected area, redness, swelling, and acute pain.

  • The soil and water components are represented by the Kapha dosha, which has an impact on Kaphaja Arbuda. This kind of cancer usually has a pale appearance, grows slowly, and tends to become congested. The symptoms of Kaphaja Arbuda include dullness or stagnation in the affected area, as well as feelings of heaviness, coldness, and tiredness.

  • An imbalance including Vata, Pitta, and Kapha doshas is known as Tridoshaja Arbuda. Each dosha's symptoms are combined in this type of cancer. The range of symptoms that patients with Tridoshaja Arbuda may encounter is contingent upon the particular dosha imbalances that are present.

Classification according to tissues involved:

Susruta's account of Dhatus in Nidana Sthana states that there are three different kinds of Dhatus engaged in Arbuda (tumor):

  • Fatty tissue, or Medaja Arbuda 

  • Mamsaja Arbuda (tissue of muscles) 

  • Blood, or Raktarbuda

Furthermore, a more detailed account exists in which Asthi (Bone) is also implicated in causing swelling similar to Arbuda, which is referred to as "Adhyasthi" rather than Asthyarbuda. In addition, Asthi Kshaya may be included in Asthyarbuda if it is restricted to a specific area that resembles a pathological fracture or an osteoclastic destructive alteration in the bone.

Understanding these Ayurvedic classifications offers a sophisticated outlook on cancer, facilitating customized therapeutic approaches that target the distinct imbalances present in the body. It is noteworthy that seeking the advice of a certified Ayurvedic practitioner is necessary for precise diagnosis and customized treatment regimens. This age-old knowledge provides a comprehensive approach to cancer treatment, emphasizing the underlying energetic imbalances as well as the physical symptoms.

Ayurvedic Approaches to Cancer Treatment

Herbal medicines and formulations

Rasayana therapy

Given the abundance of references to Rasayana therapy found in the Atharva Veda, Rasayana therapy is as old as the Vedas. Classics contain in-depth accounts of divine Rasayana agents such as Soma. Similar to Charak's description, references to Achara Rasayna and Sadvritta may also be found in Vedic scriptures. In addition, a wealth of literature exists attesting to the superiority of other popular Rasayana medications, such as Punarnava, Jivanti, and Pippali. Ajasrika Rasayana is another idea that can be found in Vedic literature. 

One of Ayurveda's comprehensive disciplines, rasayana, involves the specialized use of herbs, herbomineral formulations, food items, lifestyle, self-discipline, and social etiquette to achieve the optimal state of the body's tissues and systems and minimize the impact of etiological factors on the body. To put it another way, Rasayana is a means of achieving homeostasis, which delays the aging process and helps avoid illness. When in good health, rasayana can be seen as a nutritional dynamic for mental and physical renewal. 

Types of Rasayana therapy

  • Kutipraveshika Rasayana

    This kind of Rasayana is run from a cottage that is built in a nice location and where the necessary appliances are conveniently obtainable. The cottage (Trigarbha Kuti) has three walls. A person who wants to undergo rejuvenation therapy should enter the cottage in a favorable Muhoorta. Elimination therapy should then be administered to that person to purify them.
    The rejuvenation therapy should then be started once the patient is content and has regained strength.
    The patient often feels a little weaker after elimination therapy is administered. Consequently, for the patient to regain strength, a proper diet (Sansarjana karma) should be administered.

  • Vatatpika Rasayana

    In Trigarbha Kuti, it is not given out. It's termed Vatatpika Rasayana because it can be given even if the patient is exposed to the sun and wind.

  • Kamya Rasayana

    The most important thing that Sushruta gave to Rasayana Vigyana was the thorough classification that was included in the text and further appropriated by the renowned commentator "Dalhana." The Sushruta Samhita text and the Dalhana's commentary shed light on the idea that there are two possible aspects to Rasayana therapy:-

  1. Rasayana Kamya
    Kamya is the word for desire. Kamya Rasayana is the Rasayana used to accomplish a particular goal.
    It is further separated into Prana Kamya, Medha Kamya, and Shri Kamya, which are utilized to promote Medha, Pran, and Shri Naimitiika Rasayana in healthy individuals.

  2. Rasayana Naimitika
    to be applied to individuals with a particular illness.
    Naimitika Rasayana is meant to be applied to individuals with particular illnesses. This Rasayana is applied as a supplement to medical care for particular conditions. There is greater practical importance in Naimitika Rasayana. While naimitika rasayana is utilized as an adjuvant to specific illness management—for example, ashwagandha churna and ashwagandharishta are advised for the treatment of tuberculosis—it is not a specific medical treatment for any given condition.

  • Sanshodhana Rasayana/ Sanshamana Rasayana
    Sanshodhana Rasayana refers to the Rasayana medications that purge the body of the vitiated Doshas. Rasayana medications, such as Vamana, Veerchana, and Swedna, remove Doshas from the body. Shodnana Ramayana examples include Yashtimadhu and Pippali. Other medicines have the same effect as Dosh Shaman. We refer to these medications as Sanshamana Rasayana.

  • Medhya Rasayana
    Medha must be able to correctly correlate and comprehend what is known about the objects that are now in existence. A human would be able to learn about existent objects and so become learned as a result of Medha. The majority of Medhya Rasayana medications have a variety of qualities. As a result, it seems challenging to explain how each Medhya medication works. According to Nagarjuna, the primary mechanism of action of Medhya medicines is through their Achintya Veerya or Prabhava. Additionally, Medhya Rasayana has an impact at several levels, including those of Rasa, Agni, and Srotsa. These medications work by enhancing and boosting Agni function at the Agni level. 

Specific herbs and their potential anticancer properties

Allspice

The English gave the herb the name "allspice" in the 1600s because they believed it blended the tastes of cloves, nutmeg, and cinnamon. Other names for allspice include "Jamaica pepper," "kurundu," "myrtle pepper," "pimenta," and "new spice." Contrary to popular belief, ground allspice comes from the dried, unripe berries of the Pimenta dioica tree. The Greater Antilles, southern Mexico, and Central America are the native habitats of this tree. P. dioica is grown today in many warm regions of the globe. Additionally, allspice essential oil is sold commercially. Antimicrobial, antioxidant, anti-inflammatory, analgesic, antipyretic, anticancer, and antitumorigenic activities are all attributed to allspice. The antioxidant and antimicrobial activities of allspice may be associated with eugenol.

Allspice's capacity to affect cytochrome P450 (CYP) activity and, consequently, carcinogen bioactivation may contribute to its anticancer qualities. Researchers examined the capacity of the spice extract to activate pathways associated with phase I detoxifying enzymes in human colon and liver cancer cells. The CYP3A4 promoter was significantly activated by the allspice extract, however the pregnane X receptor (PXR) was not directly activated. Allspice function thus appears to be possible when transcription factors are activated to bind to response elements. The reaction to eugenol and allspice is particular because neither substance affected gastrointestinal glutathione peroxidase (GPx), an enzyme connected to the elimination of reactive oxygen species (ROS).

There is proof that allspice can impact the proliferation of malignant cells grown in vitro proliferate. Allspice extract decreased the viability of prostate cancer cells by approximately 50%, but it did not affect the viability of cervical epithelial carcinoma cells or human prostate cancer cell lines that were cultivated. 

Basil

A common culinary herb in Southeast Asian and Italian cuisines is basil (Ocimum basilicum). Although there are various varieties of basil, sweet basil is one of the most common and studied herbs in terms of health benefits. The antiviral, antitumorigenic, antioxidant, and antibacterial qualities of basil are probably derived from a number of substances, such as eugenol, 1,8-cineole, linalool, and estragole. 

There is proof that basil is an antimutagenic spice from several studies. In the presence or absence of liver microsomal activation, the antimutagenic properties of basil were investigated in relation to the mutagenicity of Salmonella typhimurium TA98, TA100, and TA102 cells. At doses ranging from 0.5 μL/plate to 2.0 μL/plate, the essential oil of basil reduced mutations caused by UV irradiation by 22-76%. The reduction in mutations resulting from 4-nitroquinoline-N-oxide was 23-52%, while the reduction from 2-nitropropane was 8-30%. These results are in line with research showing that in the human hepatoma (HepG2) cell line, 50 μg/mL basil significantly inhibited the production of DNA adducts induced by 1′-hydroxyestragole. This may be achieved by encouraging phase II enzymes, which would then conjugate and eliminate the carcinogen. These results probably explain why basil might lessen the carcinogenic properties of benzo(a)pyrene (B(a)P) and aflatoxin B1 (AFB1).

One of the most important repair proteins in the cellular defense against alkylation damage is DNA methyltransferase (MGMT). Human malignancies and tumors resistant to certain anticancer alkylating drugs exhibit high expression levels of MGMT. A study looked at how many medicinal herbs could increase the levels of O6-methylguanine adducts. After incubating for 72 hours, HT29 human colon cancer cell lines treated with both ethanol and aqueous extracts of basil showed a 1.25-fold rise in MGMT protein levels compared to controls. After 12 hours of incubation, basil boosted the activity of the protein glutathione-S-transferase (GST) by 1.33 fold relative to the control; after 24 hours, GST activity increased by 1.68 fold relative to the control, and after 72 hours, it decreased to 1.47 fold. One of the body's initial defenses against alkylation DNA damage is MGMT, therefore a modest increase in this enzyme (two to three times) may prevent mutagenic lesions. 

Cinnamon

Spices such as cinnamon are made from the bark of evergreen trees of the Lauraceae family. Cinnamaldehyde, eugenol, terpinene, α-pinene, carvacrol, linalool, safrole, benzyl benzoate, and coumarin are some of the main ingredients in cinnamon. Traditional Chinese medicine makes extensive use of cinnamon. 

Angiogenesis is induced by vascular endothelial growth factor (VEGF), which is a crucial element. Unfortunately, most anti-VEGF medications have side effects that make them less effective. For this reason, using naturally occurring dietary inhibitors obtained from diets is quite appealing. Because it directly suppresses the kinaseactivity of pure VEGFR2, as well as the mitogen-activated protein kinase and Stat3-mediated signaling pathway in endothelial cells (ECs), a water-based extract from cinnamon is a prospective therapeutic treatment. Remarkably, it was discovered that the extract inhibited tumor-induced blood vessel creation in vivo, sprout production from an aortic ring ex vivo, and VEGF-induced EC proliferation, migration, and tube formation in vitro. The extract's polyphenols seem to be the cause of the reaction; cinnamonaldehyde is shown to have minimal impact on VEGFR2 kinase activity.

Cumin

The flowering plant known as cumin (Cuminum cyminum) is native to India and the eastern Mediterranean region. It belongs to the Apiaceae family. The most prevalent ingredient in black cumin seed oil is thymoquinone (TQ). TQ has been shown to have chemopreventive, antibacterial, antioxidant, and anti-inflammatory qualities. It has also been shown to lessen B(a)P-induced carcinogenesis in the forestomach. 

There is a good deal of evidence that TQ can inhibit the growth of tumor cells in various types of cancer, such as osteosarcoma, breast adenocarcinoma, ovarian carcinoma, pancreatic carcinoma, colorectal carcinoma, and myeloblastic leukemia. It seems that normal cells have a small resistance to TQ. The ability of TQ to alter cell division in neoplastic cells may be explained by a number of mechanisms, including downregulation of VEGF, cyclin D1, and Bcl-xL. There is a lot of evidence that TQ can cause tumor cells to produce free radicals. As a result, pro-oxidants, or tumor cells, may have a distinct biological response from normal cells. Additionally, TQ's significance in angiogenesis has been suggested by its ability to effectively block the migration, invasion, and tube formation of human umbilical vein ECs.

In a xenograft human prostate cancer (PC-3) model, TQ (6 mg/kg/day) was also observed to inhibit tumor angiogenesis. The wide range of benefits that cumin imparts justifies its ongoing investigation as a spice with broad potential health benefits.

Garlic

Allium sativum, the garlic plant, belongs to the Alliaceae family of onions. S-alk(en)yl-L-cysteine sulfoxides and γ-glutamyl-S-alk(en)yl-L-cysteines are the main components that contain sulfur. The quantity of S-alk(en)ylcysteine sulfoxide can vary significantly; the main source is alliin (S-allylcysteine sulfoxide). 

Preclinical models offer very strong evidence that garlic and its constituents can reduce the risk of lung, esophageal, uterine, breast, colon, and skin cancers. One of the most plausible ways that garlic delays cancer development is by suppressing the synthesis of nitrosamines. The crucial function that the cysteine residue plays in inhibition is demonstrated by the capacity of S-allyl cysteine (SAC) and S-propyl cysteine to delay the synthesis of N-nitroso compounds. The strongest evidence for people comes from trials showing that 5 g/day of garlic prevented the increased excretion of nitrosoproline in the urine that was caused by excessive consumption of proline and nitrate. According to more recent data, nitroproline production may be suppressed by as little as 1 g of garlic.

Studies show that in order to achieve maximal tumor suppression, allicin must break down. Prior research findings indicated that isomolar water-soluble SAC, S-ethyl cysteine, and S-propyl cysteine were less successful in inhibiting the growth of canine carcinoma cells than lipid-soluble DAS, DADS, and DATS (100 μM). Allyl sulfur compounds suppress neoplastic cells more strongly than non-neoplastic cells. It has also been shown that DAS, DADS, and S-allylmercaptocysteine (SAMC) enhance the percentage of cells stopped within the G2/M phase. 

Ginger

As a member of the Zingiberaceae family, ginger (Zingiber officinale) is widely used as a spice and medicinal ingredient. Prostate cancer is among the many diseases for which inflammation is a major risk factor. In innate and adaptive immune responses in vivo, mitogen-activated protein kinase phosphatase-5 (MKP5) is implicated as a proinflammatory inhibitor. In normal prostate epithelial cells treated with 50 μM gingerol, providing [6]-gingerol increased MKP5 expression; similarly, it increased MKP5 expression in human prostate cancer cell lines. It has been demonstrated that ginger extracts reduce lipopolysaccharide-induced prostaglandin E2 (PGE2) production more strongly than their individual components. This inhibition is comparable to that of the nonsteroidal anti-inflammatory medication indomethacin.

Additionally, ginger seems to have antitumorigenic qualities. Ginger sensitivity has been tested on a number of cell lines. For instance, at dosages of 0.2-1 mg/mL in vitro, alcoholic extracts of ginger suppressed the growth of tumor cells in Dalton's lymphocytic ascites tumor cells and human lymphocytes. In an investigation into the cytotoxic properties of several ginger compounds against four tumor cell lines, the most powerful chemical was [6]-shogaol, whereas [4], [6], [8], and [10]-gingerol showed moderate cytotoxicity. 

In rat ascites hepatoma cells, adding [6]-gingerol has been shown to reduce proliferation and, at higher concentrations, promote apoptosis. Similarly, it has been observed that introducing [6]-shogoal to COLO295 cells causes an upregulation of the expression of the apoptosis-promoting gene GADD153. [6]-shogaol also induces apoptosis and DNA damage via a caspase-dependent, oxidative stress-mediated mechanism. In a similar vein, HEp-2 cells treated with 250 μg/mL, 500 μg/mL, or 1000 μg/mL of ginger showed dose-dependent reductions in nitrite generation, increased superoxide production, and decreased GSH levels in comparison to untreated cells, suggesting that ROS production from ginger induces apoptosis.

Diet and Nutrition

Ahara

The significance of Ahara, or the right food according to one's dosha constitution, is emphasized by Ayurveda. According to Ayurveda, a balanced diet can help the body's natural healing processes and stop toxins from building up. Moreover, Ayurveda suggests dietary modifications according to the individual constitution. Foods that are beneficial to one person's health may cause adverse effects in another.

Sattvic food or Sattvic diet

A diet that combines foods that are light, fresh, clean, and healthful is known as a sattvic diet. Simply said, a Sattvic diet consists of light, healthful, and easily digestible food. A satitvic diet provides all the nutrients and flavors in the right amounts and ratios. It adheres to moderation and stays away from extremes.

A Sattvic diet is essential for yoga practises and a healthy lifestyle. The inherent purifying qualities of sattvic food aid in the body and mind's purification. Foods that are considered sattvic are abundant in prana, or life force, and good energy that energizes the body and mind. For superior moral and intellectual discipline as well as spirituality, a sattvic diet is crucial.

Sattvik food examples:

  • Sattvic foods are those that don't stimulate the senses, such as boiling vegetables, salads, fruits, whole wheat flour, less refined rice, millets, lentils, sprouts, soups, coconut, and legumes.

  • Alkaline diet: fruit, nuts, roti, coconut water, jiggery, citrus fruits, green leafy vegetables, and fresh vegetable juice.

Rajasic food and Rajasic diet

Foods that are fiery, spicy, and stimulating are staples of a Rajasic diet. Rajasik diet is low in vital nutrients and mostly focused on flavor and sensory satisfaction rather than health. These foods cause the body and mind to become hyperactive.

Rajasic food makes up a significant portion of our diet in the modern world. Rajasic meals are by their very nature aggressive and stimulating, which has several drawbacks such causing agitation, overeating, restlessness, and stimulation of the body and mind. A diet high in Rajasic elements might exacerbate the body's Pitta and Vata doshas, or body constitutions.

You can eat this kind of cuisine in moderation. Particularly by those who have extremely active lives. Some sort of stimulating diet is necessary to support an active lifestyle.

Types of Rajasic foods

  • Rajasic food kinds include foods that stimulate the senses, such as fried, spicy, tea, coffee, tobacco, alcohol, and foods that produce gasses in the mouth.

  • Acidic foods include pickles, energy drinks, fermented foods, preserved food, sauces, fast food, and so forth.

Tamasic food and Tamasic diet

A Tajasic diet consists of foods that are poisonous, heavy, and uninteresting. The majority of Tajasik foods are highly low in nutrition and processed. Any Sattvic food turns Tamasic if it is prepared in a Tamasic manner (overcooked, stale, overindulged, etc.). These foods make you feel heavier, duller, and more lethargic in both the body and the mind.

Because everything in modern life moves so quickly, we are constantly searching for quick meals that don't sacrifice on quality. You now understand the extent to which fake and processed foods have permeated our daily diets. As a result, the majority of people experience constipation and poor digestion. Additionally, tamarisk meals contribute to a rise in ignorance, bewilderment, disorientation, and mental drowsiness.

It is advisable to stay away from tamalesic meals. However, if it must be eaten, it must be done so mindfully to avoid overindulging. When consumed in moderation, certain types of food can even aid in the treatment of certain illnesses.

Types of Tamasic foods:

  • Foods that are both stimulating and dull, such as processed, fried, cold, alcohol-infused, made with white flour, overindulging, and non-vegetarian meals, tastily prepared foods.

  • Other foods include meats, cakes, chocolates, sausages, ice cream, flavored drinks, box meals, and jam or jelly. 

Dosha-based diet

Vata-pacifying foods

Air and ether are linked to the vata dosha. Movement, nerve impulses, breathing, circulation, digestion, and creativity are all under their control. Vata folks should not go without food for an extended period of time and should consume warm meals frequently. Foods that balance the vata dosha are filling, hydrating, aid in better digestion, and help the body rid itself of impurities. 

Vata-pacifying foods include:

Fruits- 

Bananas, apples, pineapples, figs, melons, kiwis, raisins, soaked prunes, oranges, papayas, peaches, avocadoes, berries, cherries, apricots, plums, and coconuts are examples of ripe fruits that have a sweet taste. In moderation, they can also eat dried fruits. Fruits can be consumed by vata individuals one hour before or after meals, but not in the evening or later.

Vegetables-

Vata-oriented people ought to be cooked rather than uncooked. They are allowed to eat tomatoes, sweet potatoes, beets, carrots, garlic, sprouts, asparagus, zucchini, spinach, and fennel.

Grains-

Brown rice, wheat, boiling oats, wheat bread, and rice are all acceptable.

legumes. Except for moong beans, beans should be avoided.

Brown sugar and jaggery are acceptable in moderation. In moderation, they can also eat all peppers and spices. For vata folks, clarified butter, fresh milk, paneer, and tofu are all welcome. Spices like cardamom, cloves, ginger, garlic, and cinnamon can be used.

Pitta-pacifying foods

Pitta is the element of fire and water, which governs hormone function, intelligence, appetite, body temperature, and metabolism. Food that is very spicy, sour, or salty should be avoided by pitta-dom as these flavors can aggravate the pitta. People with Pitta constitutions are noted for having excellent digestion and may consume almost anything without experiencing any problems. Food shouldn't be overly hot; it should be cool or slightly warm. Summertime cuisine should be colder, such as fruit drinks or salads. Pitta types prefer their herbal drinks to have licorice or mint. For those who are pitta, a vegetarian diet is recommended. The meals they advise eating include

Fruits-

Fruits that are sweet, such as avocados, apples, coconuts, melons, oranges, dates, figs, grapes, mangoes, pomegranates, plums, and sweet cherries and berries.

Vegetables- 

Vegetables including lettuce, cauliflower, green beans, peas, potatoes, zucchini, cauliflower, mushrooms, and asparagus that can be sweet or bitter.

Grains-

You can eat rice, wheat, barley, and cooked oats.

Legumes-

Except for lentils, all legumes are acceptable for pitta patients.

Pitta-oriented persons are allowed honey and brown sugar. Spices such as cardamom, black pepper, fennel, turmeric, and cilantro are safe. Goat or cow's milk, cheese, unsalted and clarified butter, and tofu or soy milk for vegans are also acceptable foods. 

Kapha-pacifying foods

The components of earth and water come together to produce kapha dosha, which is symbolic of attributes like coldness, solidity, softness, stability, weight, and slowness. In physiology, the dosha is in charge of the body's liquids, tissues, and solidity. Foods that are drying, light, and warm are best for Kapha folks. You can eat them fresh or mildly cooked with salads and fruits. 

Steaming is not the best cooking method for Kapha; baking, broiled, grilling, or sautéing are drying ways that work better. Avoid overindulging in food if you have the kapha dosha. Foods that support healthy digestion for Kapha individuals include:

Fruits-

Berries: pears, raisins, dried figs, apples, cherries, mangoes, plums, and peaches. You should stay away from most other dried fruits.

Vegetables-

Among the bitter and spicy foods are Brussels sprouts, celery, garlic, peas, fennel, mushrooms, onions, cabbage, carrots, and eggplants.

Grains-

Moderate amounts of barley, millet, oats, and corn are available.

legumes. All the other legumes and spices are acceptable to eat, with the exception of white beans and lentils.

Lifestyle modifications

Stress management techniques

Studies conducted in lab settings using human cancer cells and animal models have produced evidence that long-term stress may exacerbate (progress) and spread (metastasize) cancer. According to one research, for instance, mice with human cancers were more likely to experience stress and have their tumors grow and spread when they were confined or kept apart from other mice.

According to research conducted in lab settings, the body releases norepinephrine during the fight-or-flight response, which in turn promotes angiogenesis and metastasis. Additionally, this hormone may stimulate neutrophils, which are immunological cells. Neutrophils have the ability to "awaken" dormant cancer cells and, in certain situations, protect tumors from the body's immune system, which aids in their growth.

The release of glucocorticoids, a class of steroid hormones, is another possible outcome of chronic stress. Glucocorticoids may promote metastasis and treatment resistance in addition to inhibiting apoptosis, a kind of tumor cell death. They might also make it more difficult for the immune system to identify and combat cancer cells.

Mind-Body practices

Mind-body practices are methods that help alter physiological, psychological, or biological processes while also enhancing quality of life. For thousands of years, people have held the concept that our thoughts and emotions can affect our physical and mental well-being. Ayurvedic, Greek, Tibetan, Chinese, and other traditional medical traditions all place a strong emphasis on the mind, emotions, and behavior in relation to health and well-being. 

The National Center for Complementary and Alternative Medicine (NCCAM) classifies body and mind therapies under one category. Mind therapies comprise practices like yoga, tai chi and qigong, meditation, and relaxation. These are usually movement- or sitting-based methods that can aid with stress management and quality of life enhancement. Other ‘body’ methods like acupuncture, massage therapy, Feldenkrais, Alexander technique, Pilates, and spinal manipulation are included in the NCCAM Mind and Body category.

Notably, studies reveal that mind-body techniques improve QOL, counteract the negative effects of stress, and alter the basic processes that occur in the brain, among other bodily systems. Neurotransmitters (such as glutamate and GABA) and neuromodulators (such as dopamine, serotonin, and adrenaline) are impacted by these activities, and they play a crucial role in regulating the stress response by preserving a balanced level of sympathetic and parasympathetic arousal. Although certain mind-body techniques require greater physical exertion than others, mind-body techniques generally have an outstanding safety record. Based on current research, there is strong evidence that mind-body techniques can be effectively used as supplemental therapy for cancer patients.

Meditation-

Many spiritual systems include meditation as one of its ancient practices. It's been called "a wakeful hypometabolic physiologic state" when the practitioner is deeply at ease but nevertheless engaged and aware. While there are many different ways to meditate, most of them have certain things in common: they involve paying close attention, breathing exercises that are regulated, and control over any thoughts or feelings that arise—regardless of whether the intention is to notice and/or suppress them. 

The most studied type of meditation is called mindfulness-based stress reduction (MBSR) and its variations. Other forms of meditation, though, have also been researched as health therapies, specifically for cancer patients. For eight weeks, MBSR is normally taught in two-hour weekly sessions in addition to a full-day retreat. A body-scan, yoga-style exercises, mindful walking meditation, and mindfulness meditation are all part of the program.

For women with breast cancer, MBSR has been employed in some capacity in the larger RCTs on meditation that have been published in recent years. Anxiety and sadness self-reports were significantly lower in MBSR-treated breast cancer patients (Stage I–III) than in standard care, and MBSR was also linked with improved sleep quality. When MBSR was used in place of standard care in British research including 229 breast cancer survivors, the long-term psychological and physical side effects of pharmacological treatments—including endocrine therapy—were lessened. An 8-week MBSR therapy was found to significantly reduce mood disturbance and stress symptoms after a baseline assessment in a recent Canadian single-arm study of 268 cancer patients.

Yoga, Tai Chi, and Qigong

In order to improve health and wellbeing, movement-based mind-body practices (such as Tibetan yoga, Indian-based yoga, and Chinese tai chi/qigong) usually incorporate physical postures or motions, breathing exercises, and meditation. One of the most popular Eastern practices in Western cultures is Indian-based yoga, or "yoga," which is Sanskrit for "to yoke" or "join." It emphasizes the harmonious synchronization of the body, breath, and mind as well as the union of mind and body. Over the past few decades, a rising amount of scientific research has revealed the potential advantages of practicing yoga for healthy and clinical populations. This ancient practice has been practiced for centuries in India to correct health problems.

An 8-session yoga intervention has been shown to improve sleep outcomes in 410 cancer survivors with moderate to severe sleep problems, according to a large, multi-center randomized controlled trial. Participants in yoga reported lower use of sleep medicines and better sleep quality as assessed by actigraphy and self-report compared to a control group receiving standard treatment. In comparison to their counterparts in a psycho-education control group, breast cancer survivors who presented with persistent fatigue responded favorably to yoga, according to a relatively modest experiment investigating treatment-related fatigue. Furthermore, the intervention decreased inflammatory signaling, which may provide insight into underlying causes. Inflammatory signaling is specifically linked to behavioral problems like weariness following breast cancer treatment. Yoga may so affect biological pathways in addition to how well patients perceive their quality of life and symptoms.

While the usefulness of yoga for males has not been well studied, tai chi/qigong has been studied in a variety of cancer groups, including male and non-gender-specific tumors. In a recent study, fatigue was observed by senior prostate cancer survivors who were randomized to either a 12-week stretching or qigong group. Findings showed that men in the stretching group experienced more weariness and distress than those in the qigong group, supporting the idea that movement-based mind-body therapies should go beyond simple physical exercise. 

It is also important to note that a number of researchers who have studied tai chi/qigong programs have included biomarkers of inflammation in addition to objective performance status measurements in order to prove the effectiveness of tai chi/qigong in cancer rehabilitation. For example, a trial measuring functional aerobic capacity and peripheral circulatory status in nasopharyngeal cancer survivors produced positive results. Finally, another study investigated how postsurgical lung cancer patients' immune function recovered after practicing tai chi. According to the results, those in the tai chi group showed less dysregulation of cellular and humoral immunity than those in the control group.

Sleep hygiene

There is evidence that several aspects of sleep, such as length, quality, circadian rhythm, and sleep disorders, can influence the risk of cancer. Nevertheless, research on this subject is not always reliable or definitive, which might be a reflection of challenges in precisely compiling long-term sleep data.

Sleep duration and cancer risk

Conflicting research has frequently been done on the relationship between the amount of sleep and cancer risk. Variations in the outcomes could be related to the methods used to gather sleep data, the kinds of cancer that are taken into consideration, and the way other variables that can affect the risk of cancer are taken into account.

According to a comprehensive study, those who get little sleep are more likely to develop cancer. In particular, short sleep duration has been linked to an increased risk of cancer-causing colon polyps. Some studies have linked shorter sleep duration in older persons to an increased risk of stomach cancer and have discovered possible associations with thyroid, bladder, head, and neck malignancies. However, these investigations are by no means conclusive.

Researchers have also examined the possibility of associations between extended sleep duration—generally understood to be more than nine hours each night—and the risk of cancer. According to one study, older persons who slept for this long had a higher chance of developing colorectal cancer, particularly if they were overweight or snorted a lot. Extended periods of sleep have been linked to a higher risk of breast and primary liver cancer.

Sleep Quality and Cancer Risk

It can be problematic to definitively assess the impact of sleep quality on cancer risk since it is frequently even harder to quantify correctly than the quantity of sleep, particularly over an extended period of time.

In mice, sleep disturbances led to different kinds of inflammation that aided in the development and spread of tumors. Researchers have discovered that persons over 50 years of age who reported having poor or moderate sleep quality had a greater chance of developing cancer.

Similar to sleep duration, more investigation is required. Future studies could clarify the relationship between the risk of acquiring a given form of cancer and particular aspects of sleep quality, such as the frequency or duration of sleep disruptions.

Detoxification and cleansing therapies

Through our diet and environmental contamination of the air, water, and soil, we are continuously exposed to potentially harmful environmental pollutants. As a result, these poisons gradually accumulate in different body tissues, which can have detrimental effects on health. Diseases begin when free radicals, a byproduct of inflammation, cause cells to malfunction and the body's capacity to eliminate toxic waste to be less than the toxic excess. In order to get rid of extra toxins and the health risks they pose, detoxification is essential. Since toxin buildup plays a major role in cellular damage and disease development, toxin removal can both prevent and possibly repair health risks including cancer.

The Ayurvedic concept of Dushi Visha is comparable to the build-up of environmental poisons over time. It is stated that this Dushi Visha interacts with Kapha, producing negative health effects. To eliminate these environmental poisons, the only therapeutic technique is panchakarma therapy, often known as detoxification therapy. Panchakarma therapy helps the body detoxify and return to normal.

There are three primary goals while performing panchakarma.

(i) Curative Panchakarma: curing a deceased person's illness; 

(ii) Preventive Panchakarma: enhancing the health of healthy ones

(iii)Conservative Panchakarma: Rehabilitative care and disease suppression.

There are three steps in the Panchakarma (detoxification) procedure.

  • Purvakarma: The necessary preparations that must be carried out prior to detoxifying

  • Pradhanakarma: The primary method of cleansing

  • Pashchat karma: Rehabilitating the food and way of life following the detoxification procedure.

Purvakarma

The process used to lubricate tissues and channels in the body, both externally and internally, using Sneha Dravyas.

(i) External oleation, or Abhayanga, which involves massaging with medicinal oils. After internal oleation is finished, external oleation is carried out. Use medicinal oil to massage the entire body or a specific section of it.

(ii) Internal oleation, or snehapana, for shaman or purification.

Internal oleation is achieved by ingesting little doses of ghee or medicinal oil. After examining the patient's body composition, the doctor decides on the length of internal oleation as well as the type, quantity, and composition of medicinal oil or ghee. 

Purvakarma-Swedana
Swedana causes sweating while relieving body stiffness, weight, and coldness. Snehana (oleation therapy) comes before Swedana. This causes the waste products that were clogging the body's channels to become unctuous and the channels to lubricate. These waste products are introduced into the Kostha, the primary channels of the body, by Swedana and then eliminated using the principal methods of Panchakarma.

Pradhanakarma- Panchakarma

  • Vamana Karma: Therapeutic vomiting or emesis therapy
    Therapeutic vomiting (Vamana) is the Ayurvedic treatment for lung congestion that causes recurrent episodes of bronchitis, colds, coughs, or asthma attacks by clearing the kapha. Emesis is deliberately instigated to facilitate the evacuation of stored poisons and vitiated doshas. Vamana detoxification is recommended for illnesses mostly involving the Kapha dosha. Additionally, therapeutic vomiting is recommended for long-term edema, lymphatic congestion, diabetes, asthma, and colds.

  • Virechana Karma: Purgation therapy
    Excess Pitta tends to build in the gall bladder, liver, and small intestine, causing rashes, acne, inflammatory skin conditions, persistent fever episodes, biliary vomiting, nausea, and jaundice. The literature on Ayurveda recommends therapeutic purgation for certain situations. Virechana is the process of purging the vitiated doshas and poisons. To guarantee thorough detoxification, this therapy can be used in conjunction with Vamana as a follow-up or as an individual detoxification session. This detoxification technique aids in the removal of poisons and vitiated doshas from the liver, intestines, and blood.

  • Basti Karma: Enema therapy
    Basti karma involves passing therapeutic liquids or oils through the urethra, vagina, or anus to remove bodily poisons and vitiated doshas. The best treatment for Vata issues is basti. Basti karma is typically carried out either solely after virechana or following the first two detoxifying procedures, Vamana and virechana. Toxins and vitiated doshas are released along with the medicinal liquids or oil that is evacuated. Uttara Basti is the practice of administering medicinal liquids and oils through the vagina in women and the urethra in men. Constipation, stomach distension, persistent fever, colds, sexual dysfunction, kidney stones, heart discomfort, backaches, sciatica, and other joint ailments are all relieved by this therapy. 

  • Nasya Karma: Errhine therapy
    Nasya is the term for medication administered by the nose. Along with nasal and oral secretions, vitiated doshas and poisons that have accumulated in the head and neck are released by the nose and mouth. Another name for this detoxification technique is Shirovirechana. The inhalation of breath through the nose brings prana, also known as nerve energy and life force, into the body. The brain contains Prana, which keeps up motor and sensory abilities. Moreover, prana regulates cognition, memory, focus, and mental processes. Nasya is recommended for convulsions, nasal congestion, migraine headaches, Prana abnormalities, and certain eye and ear issues.

  • Raktamokshaņa Karma: bloodletting therapy
    Nasya is the term for medication administered by the nose. Along with nasal and oral secretions, vitiated doshas and poisons that have accumulated in the head and neck are released by the nose and mouth. Another name for this detoxification technique is Shirovirechana. The inhalation of breath through the nose brings prana, also known as nerve energy and life force, into the body. The brain contains Prana, which keeps up motor and sensory abilities. Moreover, prana regulates cognition, memory, focus, and mental processes. Nasya is recommended for convulsions, nasal congestion, migraine headaches, Prana abnormalities, and certain eye and ear issues.

Pashchat karma

Throughout the Panchakarma treatment, a rigid diet and lifestyle regimen must be adhered to.

"Paschat Karma" refers to the therapeutic measures used to return the food and way of life to normal. At this point, the digestive system is functioning normally again. Drugs are used to treat illnesses or to revitalize the body.

Conclusion

In summary, the connections found between Ayurvedic and biological ideas in oncology offer an illustration of how knowledge sharing across conventional and contemporary systems can broaden perspectives on cancer and palliative care. Most of the time, the precise cause of cancer is unknown. Understanding various viewpoints on complicated diseases like cancer offers important insights. The Ayurvedic perspectives on the development, therapy, side effects of treatment, and supportive cancer care highlight this. The research reveals that there is a correlation between Ayurvedic and biological principles in oncology and in this era of integrated and global medicine, this conversation is especially crucial.